New approaches to thrombolytic therapy.
نویسندگان
چکیده
منابع مشابه
New approaches to thrombolytic therapy.
Tissue-type plasminogen activator (t-PA), purified from the culture fluid of a stable human melanoma cell line, is a serine protease, different from urokinase, with a molecular weight of about 70,000. It is composed of one polypeptide chain, which is converted to a two-chain molecule by limited plasmic action. Activation of plasminogen to plasmin occurs by cleavage of the Arg 560-Val 561 peptid...
متن کاملReview New Approaches to Thrombolytic Therapy
Tissue-type plasmlnogen activator (t-PA), purified from the culture fluid of a stable human melanoma cell line, Is a serlne protease, different from urokinase, with a molecular weight of about 70,000. It is composed of one polypeptlde chain, which Is converted to a two-chain molecule by limited plasmic action. Activation of plasmlnogen to plasmln occurs by cleavage of the Arg 560-Val 561 peptid...
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متن کاملThrombolytic therapy.
Thrombolytic therapy, which involves the administration of agents designed to increase fibrinolytic capacity, has been utilized in respiratory medicine for more than 50 years. A variety of agents have been used to effect thrombolysis, including urokinase plasminogen activator (uPA) and streptokinase. Tissue plasminogen activator (tPA) has also been used to effect thrombolysis. Both uPA and tPA ...
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ژورنال
عنوان ژورنال: Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
سال: 1984
ISSN: 0276-5047
DOI: 10.1161/01.atv.4.6.579